Türk Beyin Damar Hast Derg. 2006; 12(2): 33-40

NEUROLOGÝCAL AFFECT OF HOMEOSTASÝS DÝSTURBANCES

Atilla Özcan ÖZDEMÝR¹, Gazi ÖZDEMÝR¹

Homeostasis defects that it is means the disturbance between thrombotic and antithrombotic balance are usually causes in young stroke. The continuity of homeostasis is commonly the healthy of vascular reactivity, vascular endotel, subendothelial fonction and condition of thrombicyts and rheology of blood volume. Thrombositopenia and thrombocytosis are important condition in disturbances of coagulation mechanisms. Thrombositosis may lead to vasoocclusive or hemorrhagic serebral lesions according to other riscs or being use drugs. Also, in the conditions of thrombositopenia if the number of thrombocyte is 50-100.000 may occurs serebral oclusion, in the case of more decrease number serebral hemorrhage. In the serebral venous thrombosis must specially be investigated a) Blood cells diseases (Policytemia, sicle cell anemia, posthemorrhagic anemia, paroxysmal nocturnal hemoglobinuria and primary pr secondary thrombositemia) and b) Defects of coagulation (Protein C, Protein S, deficiency of antithrombine III, DIC, thrombositemia from heprin, mutation of factor V Leiden, mutation of prthrombine 20210A).

Keywords: Homeostasis, coagulation defects, thrombocytopenis, thrombocytosis

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HOMEOSTAZ BOZUKLUKLARINDA NÖROLOJÝK ETKÝLENÝM

Atilla Özcan ÖZDEMÝR¹, Gazi ÖZDEMÝR¹
Eskiþehir Osmangazi Üniversitesi Týp Fakültesi Nöroloji Anabilim Dalý, Eskiþehir

Trombotik ve antitrombotik dengelilik halinin bozulmasý demek olan homeostaz bozukluklarý, özellikle genç strok nedenleri arasýnda önemli bir yer tutmaktadýr. Bu dengelilik halinin devamlýlýðýnda vasküler reaktivite, vasküler endotel’in saðlamlýlýðý, subendotelial fonksiyon ve kan kitlesinin trombositleri ile reolojik durumu ayrý ayrý rolere sahiptirler. Trombositlerin azlýðý (trombositopeni) gibi fazlalýðý (trombositoz veya trombositemi) da koagulasyon dengesinin bozulmasýnda önemli etkenlerdir. Trombosit sayýsýnýn artýþý, diðer risk durumlarý veya ilaçlara göre deðiþmek üzere vazookluzif veya hemorajik serebral lezyonlara yol açabilir. Ayný þekilde trombositopeni durumlarýnda ve trombosit sayýsý 100-50.000 düzeyinde ise çoðunlukla serebral okluzyonlar, daha düþük sayýlarda ise serebral hemorajilere rastlanýr. Serebral venöz trombozlarda özellikle a) Kan hücre hastalýklarý (Polisitemia, sicle cell anemi, post hemorojik anemi, paraksismal nokturnal hemoglobinuri, trombositemi (primer yada sekonder) ve b) Koagulasyon Defektleri (Protein C, Protein S, Antitrombin III eksikliði, DIC, Heparine baðlý trombositopeni, Faktör V Leiden Mutasyonu, Protrombin 20210 A mutasyonu) araþtýrýlmalýdýr.

Anahtar Kelimeler: Homeostaz, koagulasyon defektleri, trombositopeni, trombositoz

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