Türk Beyin Damar Hast Derg. 2020; 26(2): 162-166 | DOI: 10.5505/tbdhd.2020.82621

Prognostic significance of atraumatic convexal subarachnoid hemorrhage in patients with cerebral amyloid angiopathy

Özlem Aykaç, Fatma Ger Akarsu, Atilla Özcan Özdemir
Eskisehir Osmangazi University, Faculty of Medicine, Department of Neurology, Eskisehir, Turkey

INTRODUCTION: Cerebral amyloid angiopathy (SAA) is a cerebrovascular pathology that develops due to the accumulation of amyloid beta-peptide (Aβ) in the media and adventisia layer of small and large cerebral arteries. Ischemic or hemorrhagic stroke, dementia and encephalopathy can be seen. In our study, we aimed to investigate the frequency of convexal subarachnoid hemorrhage and its effect on prognosis.
METHODS: Twenty-four patients diagnosed with cerebral amyloid angiopathy who were examined and treated in the neurology clinic between 2016 and 2017, and who received gradient ECO and SWI MR imaging were included in our study. Patients with a history of trauma and recent surgery were excluded from the study. Demographic features, vascular risk factors, antithrombotic or anticoagulant use, neuroimaging findings, application NIHSS and mRS values after 3 months were recorded.
RESULTS: 24 patients were included in the study. Eleven (45.8%) were women. The average age was 72.5 ± 8.79. 17% of our patients had convex subarachnoid hemorrhage and 21% had lobar hemorrhage. In 42%, both lobar hemorrhage and convex subarachnoid hemorrhage were observed. There was no significant difference between the groups in terms of prognosis and mortality.
DISCUSSION AND CONCLUSION: In our study, it was concluded that convexal subarachnoid hemorrhage did not have a significant effect on prognosis and was not related to hypertension, diabetes, smoking and anticoagulant use.

Keywords: Cerebral amyloid angiopathy, subarachnoid hemorrhage, prognosis.

---

Atravmatik konveksiyel subaraknoid kanamanýn serebral amiloid anjiyopati hastalarýnda prognostik önemi

Özlem Aykaç, Fatma Ger Akarsu, Atilla Özcan Özdemir
Eskiþehir Osmangazi Üniversitesi Týp Fakültesi, Nöroloji Anabilim Dalý, Eskiþehir

GÝRÝÞ ve AMAÇ: Serebral amilod anjiopati (SAA), küçük ve büyük serebral arterlerin media ve adventisia tabakasýnda amiloid beta-peptid (Aβ) birikimine baðlý geliþen serebrovasküler bir patolojidir. Ýskemik veya hemorajik inme, demans ve ensefalopati görülebilir. Çalýþmamýzda konveksal subaraknoid kanama sýklýðýný ve prognoz üzerine etkisini araþtýrmayý amaçladýk.
YÖNTEM ve GEREÇLER: 2016-2017 yýllarý arasýnda nöroloji kliniðinde yatarak tetkik ve tedavi edilen, gradient EKO ve SWI MR görüntüleme yapýlan olasý serebral amiloid anjiopati tanýlý 24 hasta çalýþmamýza dahil edildi. Travma öyküsü olan, yakýn zamanda cerrahi geçiren hastalar, çalýþmadan çýkarýldý. Tüm hastalarýn demografik özellikleri, vasküler risk faktörleri, antitrombotik veya antikoagülan kullanýmý, nörogörüntüleme bulgularý, baþvuru NIHSS ve 3 ay sonraki mRS deðerleri kaydedildi.
BULGULAR: Çalýþmaya 24 hasta alýndý. On bir (%45,8) kadýndý. Yaþ ortalamasý 72,5±8,79 idi. Hastalarýmýzýn %17’sinde konveksal subaraknoid kanama, %21’inde lober hemoraji mevcuttu. %42’sinde ise hem lober hemoraji hem de konveksal subaraknoid kanama izlendi. Gruplar arasýnda prognoz ve mortalite açýsýndan anlamlý fark izlenmedi.
TARTIÞMA ve SONUÇ: Çalýþmamýzda konveksal subaraknoid kanamanýn prognoz üzerinde belirgin etkisinin olmadýðý ve hipertansiyon, diabet, sigara kullanýmý, antiagregan, antikoagülan kullanýmý ile iliþkisinin olmadýðý sonucuna varýldý.

Anahtar Kelimeler: Serebral amiloid anjiopati, subaraknoid kanama, prognoz.

---

CITE