Türk Beyin Damar Hast Derg. Baskýdaki Makaleler: TBDHD-82542 | DOI: 10.5505/tbdhd.2024.82542

Bir CARASIL hastasýnda fatal serebellar hemoraji

Sümeyra Kanat¹, Ozlem Kayim Yildiz¹, Hatice Balaban², Fatih Bayraklý^3
1Cumhuriyet Üniversitesi Týp Fakültesi, Nöroloji Anabilim Dalý, Sivas
²Liv Ankara Hastanesi, Nöroloji Ünitesi, Ankara
³Bakýrköy Acýbadem Hastanesi, Beyin ve Sinir Cerrahisi Ünitesi, Ýstanbul

Subkortikal infarktlar ve lökoensefalopatiyle birlikte serebral otozomal resesif arteriopati (CARASIL), lökoensefalopati ve laküner infarktlarla karakterize monogenik herediter bir serebral küçük damar hastalýðýdýr. Klinik manifestasyonlar laküner inme, basamaklý ve / veya progresif nörolojik bozulma, vasküler demans, spondilozis ve prematür alopesidir. Ýntraserebral hemoraji bugüne dek birkaç hastada bildirilmiþtir. Fatal serebellar hemorajisi olan bir CARASIL hastasýný sunuyor ve herediter serebral küçük damar hastalýðý olan kiþilerde antiplateletlerin etkinlik ve güvenliðini tartýþýyoruz.

Anahtar Kelimeler: Subkortikal infarktlar ve lökoensefalopatiyle birlikte serebral otozomal resesif arteriopati, CARASIL, hemoraji, antiplatelet

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Fatal cerebellar hemorrhage in a patient with CARASIL

Sümeyra Kanat¹, Ozlem Kayim Yildiz¹, Hatice Balaban², Fatih Bayraklý^3
1Cumhuriyet University School of Medicine, Department of Neurology, Sivas
²Liv Ankara Hospital, Neurology Unit, Ankara
³Bakýrköy Acýbadem Hospital, Neurosurgery Unit, Ýstanbul

Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a monogenic, hereditary cerebral small vessel disease characterized by leukoencephalopathy and lacunar infarctions. The clinical manifestations are lacunar stroke, stepwise and / or progressive neurological deterioration, vascular dementia, spondylosis and premature alopecia. Intracerebral hemorrhage has been reported in only a few patients to date. We report a patient with CARASIL and fatal cerebellar hemorrhage and discuss the safety and efficacy of antiplatelets in patients with hereditary cerebral small vessel disease.

Keywords: Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy, CARASIL, hemorrhage, antiplatelet

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