AKUT STROKTA LİPİD PROFİLİ, APOLİPOPROTEİN A-1 VE APOLİPOPROTEİN B

Serebruvasküler hastalıklarda serum lipidleri ve lipoproteinleri arasındaki iliııki koroner aterosklerozdaki kadar açık de~ildir. Apolipoproteinler veya lipoproteinlerin protein komponentlerinin aterogenezisde, lipid komponentinden daha önemli olduğunu bildiren çalışmalar mevcuttur. Strok değişik etyolojilerle oluşan heterojen bir durum olduğundan hemorajik ve iskemik strok gruplarıoda akut dönemde plazma lipid faktörlerini ve hipertansiyon, atrial fibrilasyon, iskemik kalp hastalığı, diabet, yaş gibi bilinen risk faktörleri ile ilişkiyi araştırdık. 22 hemorajik, 51 İskemik olmak üzere 73 akut strok hastasında strok sonrası 48 saatteki total lipid, total kolesterol, trigliseridler, HDL kolesterol, LDL kolesterol, VLDL kolesterol, apolipoprotein A-1 ve apolipoprotein B serum düzeyleri ölçüldü. İskemik grupta Apolipoprotein B ile total lipid ( r:0,73 p< 0,001), total kolesterol (r:0,66 p<0.01), tripliserid (r:0,51 pAnahtar Kelimeler: Hemorajik strok, iskemik strok, apolipoprotein A· 1, apolipoprotein B.

LİPİD PROFİLE, APOLİPOPROTEİN A-1 AND APOLİPOPROTEİN- B IN ACUTE PERİODE OF THE STROKE

The relation between serum lipids and lipoproteins in cerebrovascular disease is not as clear cut as in coronary atherosclerosis. Some studies suggest that apolipoproteins or protein components of lipoproteins are more important than lipid components. Since stroke a heterogen condition that occurs because of various etiologic causes, we examined risk factors including lipid factors, hypertension, atrial fibrillation, ischaemic heart disease, diabetes mellitus and age in acute stage of hemorrhagic and ischaemic stroke. Serum levels of total lipid, total cholesterol, triglicerids, HDL cholesterol, LDL cholesterol, VLDL cholesterol, apolipoprotein A-1 and apolipoprotein B were measured in 22 haemorrhagic and 51 ischaemic acute stroke patients within 48 hours. In the ischaemic group, no meaningful correlation was found between HDL cho\esterol and Apolipoprotein B while a positive correlation was found between Apolipoprotein B and total lipid (r:0,73 p<0,001), total -cholesterol (r:0,66 p<0.01l), triglicerid (r:0,51 p<0,001), LDL cholesterol (r:0,58 p<0,001) and VLDL cholesterol (r:0,35 p<0.01). No meaningful mrrelation was found Apolipoprotein A-1 and triglicerid, HDL cholesterol, and VLDL cholesterol. A negative correlation was found between Apolipoprotein A-1 and total lipid (r:-0,24 p<0,05), total -cholesterol (r:-0,38 p<0,01) and LDL cholesterol (r: -0,37 p<0,01). In the emorhagic group, a negative correlation was found between Apolipoprotein A-1 and total lipid (r:-0,48 p<0,01), total cholesterol (r:-0,51 pKeywords: Haemorrhagic stroke, ischaemic stroke, apolipoprotein A-L apolipoprotein B.