ORAK H�CRE HASTALARINDA SESSIZ SEREBRAL ENFARKT SIKLI�I

BALCI, Ali; OKUYUCU, Esra; DUMAN, Ta�k�n; GAL�, Edip; KARAZ�NC�R, Sinem; MELEK, �smet; YANMAZ, Rasim; E��LMEZ, Ertu�rul

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ORAK H�CRE HASTALARINDA SESSIZ SEREBRAL ENFARKT SIKLI�I [T�rk Beyin Damar Hast Derg]

T�rk Beyin Damar Hast Derg. 2008; 14(3): 79-82

ORAK H�CRE HASTALARINDA SESSIZ SEREBRAL ENFARKT SIKLI�I

Ali BALCI¹, Esra OKUYUCU¹, Ta�k�n DUMAN¹, Edip GAL�², Sinem KARAZ�NC�R¹, �smet MELEK¹, Rasim YANMAZ³, Ertu�rul E��LMEZ³
¹Mustafa Kemal �niversitesi T�p Fak�ltesi, Radyoloji ve N�roloji AD, Antakya, Hatay
²Hatay Devlet Hastanesi, �ocuk Sa�l�� ve Hastal�klar�,Antakya, Hatay
³Mustafa Kemal �niversitesi T�p Fak�ltesi, Radyoloji,AD, Antakya, Hatay

Ama�: Orak h�cre hastalar�nda sessiz serebral enfarkt s�kl��n� ve anormal beyin manyetik rezonans g�r�nt�leme (MRG) bulgular�n� saptamakt�r. Gere� ve y�ntem: Asemptomatik orak h�cre hastal�� olan 52 hastan�n beyin MRG�leri retrospektif olarak tarand�. Anormal bulgular kaydedildi. Bulgular: Elli iki orak h�cre hastas�n�n 44�� homozigot (S/S), 8�i ise heterozigot (S/�thal) idi. K�rk d�rt S/S hastas�n�n 12�sinde (%27.2), 8 S/�thal hastas�n�n 2�sinde (%25) sessiz enfarkt saptand�. S/S hastalar�n�n 10�unda (% 22.7; 7 diff�z serebral, 2 fokal serebral, 1 serebeller) atrofi g�r�ld�. S/�thal hastalar�nda ise atrofi saptanmad�. Sonu�: Hatay�da ya�ayan orak h�cre hastalar�nda literat�r bulgular� ile paralellik g�steren y�ksek oranda sessiz serebral enfarkt ve atrofi saptand�.

Anahtar Kelimeler: orak h�cre hastal��, beyin, manyetik rezonans, sessiz enfarkt

THE PREVALENCE OF SILENT CEREBRAL INFARCT IN PATIENTS WITH SICKLE CELL DISEASE

Ali BALCI¹, Esra OKUYUCU¹, Ta�k�n DUMAN¹, Edip GAL�², Sinem KARAZ�NC�R¹, �smet MELEK¹, Rasim YANMAZ³, Ertu�rul E��LMEZ³
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Objective: To determine the prevalence of silent cerebral infarct and abnormal brain magnetic resonance imaging (MRI) findings in patients with sickle cell disease (SCD). Materials and methods: Fifty-two brain MR images of the asymptomatic patients with SCD have been reviewed retrospectively. The abnormal MRI findings were recorded. Results: Forty-four of the 52 patients with SCD were homozygous (S/S) and remaining 8 heterozygous (S/�thal) for SCD. Twelve (27.2%) of the 44 patients with S/S and 2 (25%) of the 8 patients with S/�thal had silent infarcts. Ten (22.7%; 7 diffuse cerebral, 2 focal cerebral and 1 cerebellum) of the 44 S/S patients demonstrated atrophy. None of the 8 patients with S/�thal had cerebral atrophy. Conclusion: Patients with SCD living in Hatay demonstrated a high rate of silent cerebral infarct and cerebral atrophy. These findings concur with the results of the literature.

Keywords: sickle cell disease, brain, magnetic resonance, silent infarct

Ali BALCI, Esra OKUYUCU, Ta�k�n DUMAN, Edip GAL�, Sinem KARAZ�NC�R, �smet MELEK, Rasim YANMAZ, Ertu�rul E��LMEZ. THE PREVALENCE OF SILENT CEREBRAL INFARCT IN PATIENTS WITH SICKLE CELL DISEASE. T�rk Beyin Damar Hast Derg. 2008; 14(3): 79-82
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ORAK H�CRE HASTALARINDA SESSIZ SEREBRAL ENFARKT SIKLI�I

THE PREVALENCE OF SILENT CEREBRAL INFARCT IN PATIENTS WITH SICKLE CELL DISEASE